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Boys of Tommen #1 : Binding 13

Autor: Chloe Walsh

Número de Páginas: 672

" Il n'avait qu'une obsession : le rugby. Avant elle. Elle ne désirait qu'une chose : survivre. Avant lui. " Johnny Kavanagh a tout pour lui. Sur un terrain de rugby, il est une force avec laquelle il faut compter. Prêt pour la célébrité, il se dirige tout droit vers le sommet. Rien ne peut se mettre en travers de son chemin, n'est-ce pas ? Pas même la nouvelle fille timide du lycée Tommen. Celle avec des yeux tristes et qui cache ses bleus. La vie n'a jamais été facile pour Shannon Lynch. Brimée et torturée, elle arrive en cours d'année au lycée Tommen, priant pour un nouveau départ. Dès son premier jour dans cette prestigieuse école, elle entre en contact avec le mélancolique Johnny Kavanagh. Entamant une amitié compliquée et luttant contre leur indéniable alchimie, Johnny et Shannon n'auraient jamais pu prévoir les obstacles qui menaceront leur relation naissante...

Binding 13

Autor: Chloe Walsh

Número de Páginas: 862

An epic and unforgettable love story begins in Binding 13, the first in the international bestselling and TikTok-phenomenon The Boys of Tommen series, from Chloe Walsh. The power and pain of first love has never been more deeply felt than in Chloe Walsh's extraordinary stories about the irresistible Boys of Tommen, which will give you the ultimate book hangover. The reader reaction to The Boys of Tommen says it all! 'This universe is all consuming. Chloe Walsh has some serious talent' ⭐ ⭐ ⭐ ⭐ ⭐ 'If you're looking for a beautifully written, heart wrenching, hilarious book . . . and want one hell of a book hangover, then do yourself a favour and read these pronto' ⭐ ⭐ ⭐ ⭐ ⭐ 'To say I loved this book is an understatement, It has ripped my guts out shattered my heart had me biting my nails with anticipation and bawling like a baby all in one phenomenal read' ⭐ ⭐ ⭐ ⭐ ⭐ 'I adore this world & the found family this series has brought into my life and I don't know what I was before I read this' ⭐ ⭐ ⭐ ⭐ ⭐ 'Chloe Walsh will always be my number one author' ⭐ ⭐ ⭐ ⭐ ⭐ ......................... They are from opposites sides of the track - but...

Binding 13 (Los chicos de Tommen 1)

Autor: Chloe Walsh

Número de Páginas: 980

Una historia de amor épica e inolvidable: llega en español Binding 13, el primer libro del fenómeno de TikTok Los chicos de Tommen, de Chloe Walsh Nunca habrás sentido con tanta intensidad el poder del primer amor como en este romance deportivo. ¡No podrás dejar de leer! Hasta ahora han permanecido en lados opuestos del campo, pero cuando sus dos mundos choquen, nada volverá a ser lo mismo. Johnny Kavanagh lo tiene todo a su favor. En el campo de rugby es una fuerza imparable. Ha nacido para el estrellato y nada detendrá su camino a la cima. Ni siquiera la tímida chica nueva del Instituto Tommen. La de los ojos tristes y los moratones escondidos. La que lo distrae como nunca nadie lo ha hecho. La vida nunca ha sido fácil para Shannon Lynch. Acosada y torturada por sus antiguas compañeras, llega a Tommen a mitad del año escolar, rezando por un nuevo comienzo y desesperada por librarse de los demonios de su pasado. En su primer día en la prestigiosa escuela privada, conoce, de forma bastante impactante, al famoso Johnny Kavanagh. Atrapada en un torbellino de sentimientos hacia él y desesperada por pasar desapercibida, Shannon se convierte una vez más en el blanco del...

Binding 13

Autor: Chloe Walsh

His first, last, and only true love has always been rugby. Until now. He wants to save her. She wants to hide. She's damaged. He's determined. Fate brought them together. Love binds them. Johnny Kavanagh has everything going for him. On the rugby pitch, he's a force to be reckoned with. Primed for stardom, he's heading straight for the top. Nothing can possibly get in his way, right?Not even the shy new girl at Tommen College. The one with the sad eyes and hidden bruises. The one that distracts him like no one ever has. Plagued with a hidden injury and desperate to impress the scouts watching his every move, Johnny has been placed on a pedestal so high, he has no room to make mistakes. Striving to maintain balance, and on the crest of the International Summer Campaign, Johnny needs to keep his head in the game. He needs to stay focused, and cannot afford to let distractions get in the way of the bigger picture. But what happens when a lonely girl with sad eyes becomes the only picture?Life has never been easy for Shannon Lynch. Bullied and tortured, she arrives at Tommen College mid-way through the school year praying for a fresh start and desperate to shake off the demons that...

The Teeth and Their Environment

Autor: Ralph M. Duckworth

Número de Páginas: 165

Providing a current overview of how physical, chemical and biochemical aspects of the oral environment influence tooth condition, this publication covers caries, calculus, tooth wear and erosion, and the roles of pellicle, saliva and plaque in inducing and/or moderating these conditions. It highlights topics such as new intra-oral and laboratory methods to assess tooth wear, the latest ideas on de- and re-mineralisation processes involving enamel and dentine, new insights into the tooth structure-function relationship and the site specificity of anticaries treatments. Reviews of pellicle function and of the inverse relationship between caries and calculus complete the volume. This book is recommended to all oral care scientists, laboratory and clinical researchers alike, and to lecturers in dental medicine.

The Cognitive Neuroscience of Working Memory

Autor: Naoyuki Osaka , Robert H. Logie , Mark D'esposito

Número de Páginas: 418

Working memory has been one of the most intensively studied systems in cognitive psychology. It is only relatively recently however that researchers have been able to study the neural processes might underlie working memory, leading to a proliferation of research in this domain. The Cognitive Neuroscience of Working Memory brings together leading researchers from around the world to summarize current knowledge of this field, and directions for future research. An historical opening chapter by Alan Baddeley and Graham Hitch sets the context for the subsequent chapters. The scope of the book is exceptionally broad, providing a showcase for cutting edge research on all contemporary concepts of working memory, using techniques from experimental psychology, single cell recording, neuropsychology, cognitive neuroimaging and computational modelling. The Cognitive Neuroscience of Working Memory will be an important reference text for all those seeking an authoritative and comprehensive synthesis of this field.

Molecular Analyses

Autor: Scott Orland Rogers

Número de Páginas: 376

DNA and RNA extraction methods from a variety of tissues and samples are now routine, including extraction from single cells. Many methods are now automated. Sequencing efficiency has reached the point where it is now possible to obtain gigabases of data, both quickly and inexpensively. Such methods permit the identification of gene versions, including those associated with disease (e.g. small nucleotide polymorphism analyses, or SNPs). The general public as well as clinicians can now access a wide variety of literature on the molecular bases of diseases, allowing them to better assess disease risks and treatments. This volume concentrates on medically-focused methods, and therefore the major audience will be medical professionals, students, and those involved in medically-related research endeavors. There are also papers in this volume dealing specifically with methods developed to analyze large sequence data sets. Many methods reviewed herein are more broadly applicable to other fields in biology, chemistry, bioinformatics, and bioengineering, and are intended for a broad readership. Key Features Summarizes nucleic acid extractions from a wide variety of tissues and cells...

Grover Park George on Access

Autor: George Hepworth

Número de Páginas: 508

A textbook and study guide for new and intermediate Microsoft Access users, this book takes Access developers through the development process step by step. Terms and concepts are explained as they arise and relevant examples are provided to keep users on track and to teach them how to the use the appropriate Access features in the same context in which they will use them in their own work. Users are guided through the process of creating a working database from the first step (defining the business problem it is intended to solve) through the last (deploying the application into an organization and providing ongoing support to users). Also included are case studies that provide practical guidelines for situations Access users might find themselves in.

The Budget of the United States Government

Autor: United States. Bureau Of The Budget

Número de Páginas: 992

Drug Transporters

Autor: Glynis Nicholls , Kuresh Youdim

Número de Páginas: 270

Understanding and quantifying the effects of membrane transporters within the human body is essential for modulating drug safety and drug efficacy. The first volume comprehensively reviewed current knowledge and techniques in the transporter sciences and their relations to drug metabolism and pharmacokinetics. In this second volume on Drug Transporters, emphasis is placed on emerging sciences and technologies, highlighting potential areas for future advances within the drug transporter field. The topics covered in both volumes ensure that all relevant aspects of transporters are described across the drug development process, from in silico models and preclinical tools through to the potential impact of transporters in the clinic. Contributions are included from expert leaders in the field, at-the-bench industrial scientists, renowned academics and international regulators. Case studies and emerging developments are highlighted, together with the merits and limitations of the available methods and tools, and extensive references to reviews on specific in-depth topics are also included for those wishing to pursue their knowledge further. As such, this text serves as an essential...

Craniofacial Sutures

Autor: David P. Rice

Número de Páginas: 249

"In this volume craniofacial developmental and evolutionary biologists, oral and maxillofacial surgeons, orthodontists as well as pediatric and plastic surgeons will find a wealth of recent information on the field of craniofacial development, deformity and its treatment."--BOOK JACKET.

Decisions of the Comptroller General of the United States

Autor: United States. General Accounting Office

Número de Páginas: 1796

House Documents, Otherwise Publ. as Executive Documents

Autor: United States. Congress. House

Número de Páginas: 1254

G Protein-Coupled Receptors

Autor: David Poyner , Mark Wheatley

Número de Páginas: 310

G-Protein Coupled Receptors (GPCRs) are not only the largest protein family in the human genome but are also the single biggest target for therapeutic agents. Research into GPCRs is therefore growing at a fast pace and the range of techniques that can be applied to GPCRs is vast and continues to grow. This book provides an invaluable bench-side guide into the best and most up-to-date techniques for current and future research on GPCRs. With contributions from leading international authorities, this book equips readers with clear and detailed protocols for both well-known and up-and-coming techniques along with hints and tips for success. All the methods have been tried and tested by leading international research labs and are presented in easy-to-follow stages along with a useful overview of each technique. This book is an essential resource for all researchers in molecular biology, biochemistry, pharmacology and for graduate students.

Code of Federal Regulations

Número de Páginas: 2828

Special edition of the Federal Register, containing a codification of documents of general applicability and future effect ... with ancillaries.

Fibrinolysis in Disease - The Malignant Process, Interventions in Thrombogenic Mechanisms, and Novel Treatment Modalities, Volume 2

Autor: Pia Glas-greenwalt

Número de Páginas: 344

Fibrinolysis in Disease reviews the state of the art of basic and clinical aspects of the fibrinolytic enzyme system. The text, authored by outstanding and internationally known investigators, is presented in two books. The Malignant Process, Interventions in Thrombogenic Mechanisms, and Novel Treatment Modalities discusses the molecular biology of the system's key components and their fundamental roles in a variety of thrombotic and metabolic disorders. Molecular and Hemovascular Aspects of Fybrinolysis presents the latest findings and concepts of the association between plasminogen activator (u-PA) overexpression and abnormal growth regulation in a variety of solid tumors and in leukemia. One chapter deals with various successful interventions in thrombogenic mechanisms, ranging from exercise and diet to anticoagulants and direct and indirect thrombolytic agents. It concludes with a projection of exciting, novel treatment modalities in thrombotic and malignant diseases.

OECD Corporate Governance Factbook 2023

Autor: Oecd

Número de Páginas: 200

The OECD Corporate Governance Factbook provides easily accessible and up-to-date information on the institutional, legal and regulatory frameworks for corporate governance across 49 jurisdictions worldwide. Issued every two years, the Factbook complements the G20/OECD Principles of Corporate Governance and serves as a useful tool to track how the Principles are being implemented.

Cytochrome P450

Autor: Eric F. Johnson , Michael R. Waterman

Número de Páginas: 461

Human genomics and genetics; Structure and mechanism; Regulation of expression; Metabolism; Invertebrate P450s.

Advances in Biomembranes and Lipid Self-Assembly

Número de Páginas: 226

Advances in Biomembranes and Lipid Self-assembly, Volume 31, formerly titled Advances in Planar Lipid Bilayers and Liposomes, provides a global platform for the study of cell membranes, lipid model membranes and lipid self-assemblies, from the micro- to the nanoscale. As planar lipid bilayers are widely studied due to their ubiquity in nature, this book presents research on their application in the formulation of biomimetic model membranes, and in the design of artificial dispersion of liposomes. Moreover, the book discusses how lipids self-assemble into a wide range of other structures, including micelles and the liquid crystalline hexagonal and cubic phases. Chapters in this volume present both original research and comprehensive reviews written by world leading experts and young researchers. - Surveys recent theoretical and experimental results on lipid micro- and nanostructures - Presents potential use applications, such as clinically relevant diagnostic and therapeutic procedures, biotechnology, pharmaceutical engineering and food products - Includes both original research and comprehensive reviews written by world-leading experts and young researchers - Provides a global...

The Mechanism of Action of Androgens

Autor: W.i.p. Mainwaring

Número de Páginas: 184

My introduction to androgens was neither auspicious nor impressive. I was sitting my viva voce examination for a degree in physiology and had haltingly intimated to my examiner (name decorously withheld) that I intended to pursue a career in re search. "On what topic?" was the reply. I had been deeply impressed by the work of C. Huggins and C. V. Hodges (Cancer Res. 1, 293, 1941) on the dramatic arrest of canine prostatic hyperplasia by the administration of stilboestrol. With some en thusiasm, I responded, "On steroid hormones, because I am struck by the profound effects that may be achieved by relatively small numbers of molecules. " The examiner sank into deep contemplation before replying, "Young man, have you considered go ing into teaching?" Suitably chastened, I finally began my research career investigating the effects of steroids on the nucleic acid metabolism of experimental tumours and on the process cells. Reaching an impasse in this work, I mentioned one of senescence in animal day to Dr. G. F. Marrian that, somewhat surprisingly, we had no understanding of the fundamental mechanism of action of steroid hormones, especially the androgens. me to tackle this problem,...

Message of the President of the United States Transmitting the Budget for the Service of the Fiscal Year Ending ...

Autor: United States

Número de Páginas: 1044

Regulation of Organelle and Cell Compartment Signaling

Autor: Ralph A. Bradshaw , Edward A. Dennis

Número de Páginas: 553

"Cell signaling, which is also often referred to as signal transduction or, in more specialized cases, transmembrane signaling, is the process by which cells communicate with their environment and respond temporally to external cues that they sense there. All cells have the capacity to achieve this to some degree, albeit with a wide variation in purpose, mechanism, and response. At the same time, there is a remarkable degree of similarity over quite a range of species, particularly in the eukaryotic kingdom, and comparative physiology has been a useful tool in the development of this field. The central importance of this general phenomenon (sensing of external stimuli by cells) has been appreciated for a long time, but it has truly become a dominant part of cell and molecular biology research in the past three decades, in part because a description of the dynamic responses of cells to external stimuli is, in essence, a description of the life process itself. This approach lies at the core of the developing fields of proteomics and metabolomics, and its importance to human and animal health is already plainly evident"--Provided by publisher.

Polyamine Cell Signaling

Autor: Jian-ying Wang

Número de Páginas: 486

Polyamines are organic cations found in all eukaryotic cells and intimately involved in, and required for, distinct biological functions. An increasing body of evidence indicates that the regulation of cellular polyamines is a central convergence point for the multiple signaling pathways driving various cellular functions. Over the last decade, considerable progress has been made in und- standing the molecular functions of cellular polyamines. These significant findings provide a fundamental basis to not only define the exact role of polyamines in physiology, but also to develop new therapeutic approaches for cancers and other diseases. The major objective of this book is to provide a timely and long lasting guide for investigators in the fields of polyamines, physiology, pharmacology, and cancer research. It will provide a foundation based on research and address the potential for subsequent applications in clinical practice. Polyamine Cell Signaling: Physiology, Pharmacology, and Cancer Research is divided into four main parts: Part I: Polyamines in Signal Transduction of Cell Proliferation Part II: Polyamines in Cellular Signaling of Apoptosis, Carcinogenesis, and Cancer...

William Morris in Appliqué

Autor: Michele Hill

Número de Páginas: 232

Capture the glory of the historic textile designer’s work in exquisite appliqué quilts, cushions, and wallhangings, featuring an array of motifs. No artist ever captured the beauty of nature in such exquisite detail as William Morris. Now Michele Hill has transformed his graceful birds, flowers, vines, and woodland creatures into appliqué designs any quilter can master. • Turn William Morris' designs into 6 lovely appliqué projects: quilts, cushions, and wallhangings • Mix and match more than 50 appliqué motifs to create your own William Morris-inspired designs • Make your masterpiece quickly with easy fusible appliqué

Neuronal Activity in Tumor Tissue

Autor: Kurt S. Zänker , Frank Entschladen

Número de Páginas: 181

This book summarizes the current knowledge on how tumors interact with the nervous system and what impact this might have for the progression and treatment of cancer. It begins with an introduction to the organization and physiology of the nervous system, especially of the peripheral nervous system with its high degree of plasticity. Subsequent chapters discuss the interaction between peripheral nerves and tumor cells, the so-called neuro-neoplastic synapse, with regard to carcinogenesis, predictive tumor markers, tumor growth and tumor progression leading to metastasis. In this part, the concept of neoneurogenesis is postulated as a process by which the tumor regulates its own innervation through the release of neurotrophic factors, in analogy to the process of neoangiogenesis discovered three decades ago. Once nerve endings have grown into the tumor, these can release neurotransmitters which promote tumor cell migration and metastasis development. The final chapters reflect on the role of stem cells in neoneurogenesis and consider pharmacological approaches for the inhibition of neuro-neoplastic interactions as a basis for new anticancer therapies. Targeted primarily at...

The Enzyme Reference

Autor: Daniel L. Purich , R. Donald Allison

Número de Páginas: 940

The aim of this work is to provide a fuller spectrum of information in a single source on enzyme-catalyzed reactions than is currently available in any published reference work or as part of any Internet database. The Enzyme Reference: A Comprehensive Guidebook to Enzyme Nomenclature, Reactions, and Methods includes 20,000 review articles and seminal research papers. Additionally, it provides a novel treatment of so-called ATPase and GTPase reactions to account for the noncovalent substratelike and productlike states of molecular motors, elongation factors, transporters, DNA helicases, G-reulatory proteins, and other energases. - Includes a compendium of over 6,000 enzyme reactions (including enzyme commission numbers, alternative names, substrates, products, alternative substrates, and properties) - Covers over 900 chemical structures of key metabolites and cofactors - Index directs readers to the exact pages for over 9,500 enzyme names

Making Books for Fun!

Autor: Dana Meachen Rau

Número de Páginas: 26

Discusses the history, techniques, and supplies needed to make a book. Includes six projects. Suggested level: primary, intermediate.

Cooperativity Theory in Biochemistry

Autor: T.l. Hill

Número de Páginas: 468

During the past few decades we have witnessed an era of remarkable growth in the field of molecular biology. In 1950 very little was known of the chemical constitution of biological systems, the manner in which information was trans mitted from one organism to another, or the extent to which the chemical basis of life is unified. The picture today is dramatically different. We have an almost bewildering variety of information detailing many different aspects of life at the molecular level. These great advances have brought with them some breath-taking insights into the molecular mechanisms used by nature for rep licating, distributing and modifying biological information. We have learned a great deal about the chemical and physical nature of the macromolecular nucleic acids and proteins, and the manner in which carbohydrates, lipids and smaller molecules work together to provide the molecular setting of living sys tems. It might be said that these few decades have replaced a near vacuum of information with a very large surplus. It is in the context of this flood of information that this series of monographs on molecular biology has been organized. The idea is to bring together in...

International Law for Antarctica

Autor: Francesco Francioni , Tullio Scovazzi

Número de Páginas: 710

The volume is the result of an on-going research project on the Antarctic regime being carried out in various Italian universities and open to the participation of scholars and experts from different countries. Two concomitant factors led to the undertaking of the project: the increasing interest aroused by Antarctica in the scientific community, and the dynamic evolution of the Antarctic question in international law and politics. The result is something different from simply a second edition of a previous book, as it was clear that certain topics required entirely new treatment, especially environmental protection, liability, and institutional development. The editors tried to carefully co-ordinate the 21 individual contributions so as to properly cover the whole range of topics while at the same time preserving the pluralistic character of the book.

Joint Documents of the State of Michigan

Autor: Michigan

Número de Páginas: 778

Renal Cell Carcinoma

Autor: Robert A. Figlin , W. Kimryn Rathmell , Joanna Bloom

Número de Páginas: 327

This book provides a comprehensive look at renal cell carcinoma, exploring its biology as well as current and future molecular targets for renal cancer carcinoma.

Federal Register

Número de Páginas: 724

Metal-Ligand Interactions in Organic Chemistry and Biochemistry

Autor: A. Pullman , N. Goldblum

Número de Páginas: 397

The 9th Jerusalem Symposium was dedicated to the memory of Professor Ernst David Bergmann. An imposing and deeply moving memorial session, chaired by Professor Ephraim Katzir, the President of the State of IsƯ rael and a close friend of Professor Bergmann preceded the Symposium itself. During this session, Professor Bergmann's personality, scienƯ tific achievements and contributions to the development of his country were described and praised, besides President Katzir, by Professor A. Dvoretzky, President of the Israel Academy of Sciences and Humanities, Professor D. Ginsburg, Dean of the Israel Institute of Technology in Haifa and the author of these lines. May I just quote short extracts from these speeches. President Katzir: "As we open this ninth in the series of symposia initiated in 1967, it is difficult for me as, I am sure, for many of Ernst Bergmann's friends, co-workers and students, to be here without him. He was not only a great scientist and a beloved teacher, he was one of the most important founders of science in this country. To him we owe many institutes and the establishment here of many branches of science." Professor Dvoretzky: "Ernst Bergmann's greatness did ...

Mass Transportation Assistance to Meet the Needs of Elderly and Handicapped Persons

Autor: United States. Congress. House. Committee On Public Works And Transportation. Subcommittee On Surface Transportation

Número de Páginas: 244

Documents Accompanying the Journal of the House of Representatives

Autor: Michigan

Número de Páginas: 352

Plant Hormones and their Role in Plant Growth and Development

Autor: P.j. Davies

Número de Páginas: 690

Plant hormones playa crucial role in controlling the way in which plants grow and develop. While metabolism provides the power and building blocks for plant life it is the hormones that regulate the speed of growth of the individual parts and integrate these parts to produce the form that we recognize as a plant. In addition, they playa controlling role in the processes of reproduction. This book is a description of these natural chemicals: how they are synthesized and metabolized; how they work; how we measure them; and a description of some of the roles they play in regulating plant growth and development. This is not a conference proceedings but a selected collection of newly written, integrated, illustrated reviews describing our knowledge of plant hormones and the experimental work which is the foundation of this knowledge. The information in these pages is directed at advanced students and professionals in the plant sciences: botanists, biochemists, molecular biologists, or those in the horticultural, agricultural and forestry sciences. It is intended that the book should serve as a text and guide to the literature for graduate level courses in the plant hormones, or as a...

Documents Relating to the Foreign Relations of the United States with Other Countries During the Years from 1809 to 1898

Número de Páginas: 1074

A collected set of congressional documents of the 11th to the 55th Congress, messages of the Presidents of the United States, and correspondence of the State Dept. Many of these pamphlets have been catalogued separately under their respective headings.

Endocrine Toxicology

Autor: J. Charles Eldridge , James T. Stevens

Número de Páginas: 468

With contributions by international experts in academia, chemical manufacturing, government research laboratories, regulatory agencies, and private consulting, this guide explores the potentially damaging influence of environmental agents on the endocrine system. It examines endocrine toxicology's increased importance in environmental safety issues

Report of the Librarian for ...

Autor: United States. Department Of Agriculture. Library

Número de Páginas: 264

Structure-Performance Relationships in Surfactants

Autor: Kunio Esumi , Minoru Ueno

Número de Páginas: 820

In response to intensifying interest on surfactant research brought on by recent innovation, Structure-Performance Relationships in Surfactants, Second Edition examines novel developments in our understanding of the properties and performance of surfactants at air-liquid, liquid-liquid, and solid-liquid interfaces, highlighting seven new chapters and carefully updated material to reflect current trends. This edition presents new material on the adsorption of vesicle-forming surfactants at the air-water interface, fluorinated surfactants having two hydrophobic chains, surface-active properties of telomer-type surfactants having several hydrocarbon chains, and the association behavior of amphiphilic dendritic polymers, among many other topics.