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Neuropathology and Genetics of Dementia

Autor: Markus Tolnay , Alphonse Probst

Número de Páginas: 259

This volume is the proceedings from the Swiss Society for Neuropathology XVIIIth International Winter Meeting on Neuropathology and Genetics of Dementia, held March 23-26, 2000, in St. Moritz, Switzerland. For more than 35 years the Swiss Society of Neuropathology has organised its traditional International Winter Meeting, whose main aim is to bring together neuropathologists and clinicians as well as neuroscientists interested in disease mechanisms. The topic of the 2000 Meeting was Neuropathology and Genetics of Dementia. A programme of invited plenary lectures of high educational value as well as platform and poster presentations given by many participants covered the broad spectrum of dementing disorders. Encouraged by the high standard of the meeting, and probably also influenced by the advent of a new Millennium, it was decided to publish the Proceedings of the 2000 Meeting in the present book.

Neurodegeneration

Autor: Dennis Dickson , Roy O. Weller

Número de Páginas: 497

Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology. In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries. Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within cells (e.g. tau, α-synuclein and TDP-43) and in the extracellular compartments (e.g. β-amyloid and prion proteins) or according to a shared pathogenetic mechanism, such as trinucleotide repeats, that are a feature of specific genetic disorders. Chapters throughout the book conform to a standard lay-out for ease of access by the reader and are written by a panel of International Experts Since the first edition of this book, major advances have been made in the discovery of common molecular mechanisms between many neurodegenerative diseases most notably in the frontotemporal lobar degenerations...

Inmunología clínica

Autor: Robert R. Rich , Thomas A. Fleisher , William T. Shearer , Harry Schroeder , Anthony J. Frew , Cornelia M. Weyand

Número de Páginas: 1394

- Aborda temas de actualidad como el papel de la genética y la genómica en la respuesta inmune y las enfermedades inmunológicas, la aterosclerosis, los síndromes febriles recurrentes, en envejecimiento y las deficiencias inmunitarias, el papel de la microbiota en el desarrollo normal del sistema inmunitario y la patogénesis de las enfermedades inmunológicas e inflamatorias o las nuevas terapias. - La estricta organización de los capítulos facilita la comprensión de la información gracias a los resúmenes, tablas y gráficos que proporcionan una completa información sobre los mecanismos inmunológicos. - El formato fácil de usar presenta cuadros con códigos de colores que resaltan información crítica sobre conceptos clave, perlas clínicas, relevancia clínica y principios terapéuticos. - Resume la investigación y los desarrollos más prometedores previstos para los próximos 5-10 años en forma de prácticos recuadros. - La nueva edición ha actualizado la mayor parte de los capítulos. - En la versión online se han completado los textos con un banco de preguntas basado en casos clínicos que sirven para consolidar los conocimientos del lector. Esta quinta...

Neurología Práctica

Autor: José Biller

Número de Páginas: 0

La cuarta edici n de este manual, completamente revisada y actualizada, es una alternativa concisa a los tratados de neurolog a. El texto se presenta en apartados numerados y organizados jer rquicamente, lo que permite al lector obtener la informaci n precisa con rapidez y seguridad. Los 58 cap tulos cubren una amplia gama de s ntomas y trastornos neurol gicos habituales en la pr ctica diaria. La secci n I consta de 35 cap tulos centrados en la informaci n necesaria para realizar el diagn stico de los trastornos neurol gicos. La secci n II se compone de 23 cap tulos sobre el tratamiento de dichos trastornos, e incluye adem s los principios b sicos del abordaje de las urgencias neurol gicas. Todo ello, tratando de acercarse al d a a d a del trabajo con pacientes que padecen alg n tipo de enfermedad neurol gica y alej ndose de la complejidad que a menudo presentan las obras de esta especialidad.

Neuropathology of Aging and Alzheimer's Disease

Autor: Rudy J. Castellani

Número de Páginas: 351

Neuropathology of Aging and Alzheimer's Disease takes a foundational approach to the topic by offering basic scientific information and the latest advancements in the field. The focus of this reference is on neuropathology and recent advances in tissue characterization in aging, and in Alzheimer's Disease. Neuropathology has direct relevance to therapeutic constructs and allows for an in-depth understanding of disease pathogenesis. It is a synthesis of the salient issues with respect to pathology, pathogenesis, diagnosis, disease, normal aging, biomarker relevance, and prospects for therapeutic intervention. Detailed discussion and analysis of early Alzheimer's disease investigators and their findingsDetailed discussion and analysis of the often-overlooked literature from the 1920's to the 1960'sDetailed discussion and analysis of aging-related phenomena currently under studyDetailed discussion and analysis of punch-drunk syndrome and the transition to modern understanding of chronic traumatic encephalopathyDetailed discussion and analysis of the pathology of autosomal dominant Alzheimer's disease and Alzheimer's disease associated with Down syndromePractical issues with...

Neurodegenerative Diseases

Autor: M. Flint Beal , Anthony E. Lang , Albert C. Ludolph

Número de Páginas: 1009

Neurodegenerative diseases are major contributors to disability and disease, with Alzheimer's and Parkinson's diseases the most prevalent. This major reference reviews the rapidly advancing knowledge of pathogenesis and treatment of neurodegenerative diseases in the context of a comprehensive survey of each disease and its clinical features. The editors and contributors are among the leading experts in the field internationally. Covering basic science, diagnostic tools and therapeutic approaches, the book focuses on all aspects of neurodegenerative disease, including the normal aging process. The dementias, prion diseases, Parkinson's disease and atypical parkinsonisms, neurodegenerative ataxias, motor neuron diseases, degenerative diseases with chorea, iron and copper disorders, and mitochondrial diseases, are all methodically presented and discussed, with extensive illustrations. In each case the underlying genetics, neuropathological and clinical issues are fully reviewed, making this the most complete as well as the most authoritative reference available to clinicians and neuroscientists.

The Neuropathology of Dementia

Autor: Margaret M. Esiri , Virginia M. -y. Lee , John Q. Trojanowski

Número de Páginas: 600

Completely rewritten and updated, this new edition is almost twice the size of its predecessor. Illustrated in colour throughout, and with contributions from the world's leading authorities, it is the definitive reference on the neuropathology of dementia. It gives practical guidance to pathologists, describes the contribution of neuroimaging to diagnosis, and surveys the clinical features of dementia. New material includes: Three entirely new chapters on neuroimaging, molecular diagnostics, and transgenic models. Two chapters on tauopathies under new authorship. A chapter under new authorship on synucleinopathies, which includes multiple system atrophy.

Human Caspases and Neuronal Apoptosis in Neurodegenerative Diseases

Autor: Anil Gupta

Número de Páginas: 244

Human Caspases and Neuronal Apoptosis in Neurodegenerative Diseases elucidates elaborately the role of caspase enzymes implicated in the initiation of molecular events leading to neuronal apoptosis in the neurodegenerative disease. The book starts with introduction to neuropathology, neurogenetics, and epidemiology of neurodegenerative disease and illustrates the involvement of human caspases, neuronal apoptosis, apoptotic pathways, genetic polymorphisms, and several other factors and underlying mechanisms in the pathology of Alzheimer's disease, Parkinson's disease, and Huntington's disease. An important focus in all chapters is the intricate mechanisms and interplay that occur during or leading to neuron death in neurodegenerative diseases, along with disease pathobiology. - Provides in-depth knowledge about neurotoxic potential of transition metals, impaired mitochondrial dynamics in the brain neurons, mutant proteins Aß peptide, tau protein, a-synuclein, huntingtin protein and formation of Lewy bodies, reactive oxygen and nitrogen species, ubiquitin proteasome dysregulation, and many others in neurodegenerative diseases - Elucidates neurogenetics of gene APP, gene PSEN1, gene ...

Neurología Clínica, 2 vols. + e-dition

Autor: Walter G. Bradley , Robert B. Daroff , Gerald Fenichel , Joseph Jankovic

Número de Páginas: 2670

Nueva edición de la obra de referencia en neurología, que incluye todo lo relacionado con la neurociencia clínica y ofrece no sólo una descripción de las enfermedades neurológicas y su fisiopatología, sino también un método práctico para su diagnóstico y tratamiento. Esta 5.a edición presenta un novedoso diseño a todo color, incluyendo un gran número de nuevas tablas, figuras e imágenes radiográficas, todo ello estructurado muy racionalmente para que la lectura y localización de la información sea lo más asequible posible. Para esta edición se ha reescrito completamente el texto y casi una quinta parte de los capítulos han sido preparados por autores nuevos en el cuadro de colaboradores. En la sección de 'Neurofisiología Clínica' se incluyen dos nuevos subcapítulos, que abordan la estimulación magnética transcraneal, que refleja los últimos avances en el campo de la clínica. La obra analiza los avances derivados del florecimiento de la neurociencia, especialmente en la disciplina de neurogenética, en la cual se describe cómo la investigación en la regeneración del sistema nervioso y la biología de las células madre empieza a ser una esperanza...

Biomedical Index to PHS-supported Research

Número de Páginas: 1398

International Neurology

Autor: Robert P. Lisak , Daniel D. Truong , William M. Carroll , Roongroj Bhidayasiri

Número de Páginas: 787

This unique textbook deals with the variations in the causes, presentations and treatment of neurological disease throughout human populations. International Neurology is an indispensable guide to the full range of neurological conditions you will see in your ever-changing patient population. Comprehensive coverage of neurological diseases and disorders with a clinical approach to diagnosis, treatment and management Truly international authorship distils expert knowledge from around the world Succinct, bite-sized, templated chapters allow for rapid clinical referral Further reading recommendations for each chapter guide readers requiring more depth of information Endorsed by the World Federation of Neurology

Biomedical Index to PHS-supported Research: pt. A. Subject access A-H

Número de Páginas: 1398

The Molecular Immunology of Neurological Diseases

Autor: Sunil Kumar

Número de Páginas: 178

The Molecular Immunology of Neurological Diseases provides a comprehensive review of current updates in molecular immunogenetics of different neurological diseases. Readers will learn about the role of immune cells and their modulation strategies to help in the development of therapeutic approaches for both acute and chronic neurodegenerative disorders. There is no other book available on the topic. It has long been thought that the brain is an immune-privilege organ with very limited immune response. However recent studies have made clear that both systemic 'brain' and peripheral 'blood' immune cell responses play key roles in determining brain pathology in neurodegenerative disorders. This book summarizes the role of immune cell activation in the central nervous system microenvironment in acute and chronic neurodegenerative disorders. In addition, it discusses the key role of immune cells and their modulation strategies for the development of current therapeutic approaches. Discusses the molecular immunogenetics of different neurological diseases Covers strategies for the development of therapeutic approaches Encompasses both acute and chronic neurogenerative disorders Describes ...

Anatomic Pathology Board Review

Autor: Jay H. Lefkowitch

Número de Páginas: 618

Featuring hundreds of multiple-choice questions and full-color illustrations, Anatomic Pathology Board Review serves as a comprehensive resource for both certification and recertification exams. This fully updated medical reference book contains chapters covering general pathology, the major organ systems, and ancillary diagnostic techniques, as well as important topics including immunohistochemistry, cytopathology, and molecular diagnostics. It's the perfect tool to help you be as prepared as possible for the Anatomic Pathology boards! - Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. - Understand why an answer is correct or incorrect with help from brief explanations accompanying each. - Access coverage of all of the major organ systems and ancillary diagnostic techniques. - Prepare for the boards with updated coverage of all of the most important topics on the anatomic pathology board exam, as well as over 900 MCQs, 835 full-color illustrations, and a format that mimics that of the actual test. - Easily find specific diagnostic entities through a new Index to Images and Topics. - Get a clearer view of critical ...

The Behavioral Neurology of Dementia

Autor: Bruce L. Miller , Bradley F. Boeve

Número de Páginas: 491

Distils the most valuable discoveries in dementia research into clear, insightful chapters written by international experts.

Bradley y Daroff. Neurología clínica

Autor: Joseph Jankovic , John C Mazziotta , Scott Pomeroy , Nancy J. Newman

Número de Páginas: 2865

- Aborda, con gran claridad expositiva, todos los aspectos de la neurología actual desde la perspectiva de la práctica clínica. - Facilita la consulta mediante una organización intuitiva tanto por síntomas/signos como por grupos de enfermedades. - Presenta contenidos nuevos y ampliados sobre trastornos del movimiento, trastornos genéticos e inmunitarios, neurología tropical, neurooftalmología y neurootología, cuidados paliativos, neurología pediátrica, y tratamientos nuevos y en desarrollo. - Ofrece acceso a Expert Consult, donde encontrará la versión electrónica del libro, así como detallados vídeos que describen las manifestaciones de los trastornos neurológicos, las crisis comiciales, los registros electroencefalográficos, la estimulación encefálica profunda para la EP y el temblor, los trastornos del sueño, los trastornos del movimiento, las oscilaciones oculares, la evaluación del EMG, las neuropatías craneales y los trastornos de la neurona motora superior e inferior, así como otros signos neurológicos. Los contenidos de Expert Consult están íntegramente en inglés La nueva edición de Bradley y Daroff. Neurología clínica es una práctica...

Bradley and Daroff's Neurology in Clinical Practice - E-Book

Autor: Joseph Jankovic , John C. Mazziotta , Scott L. Pomeroy

Número de Páginas: 3032

A practical, dynamic resource for practicing neurologists, clinicians and trainees, Bradley and Daroff's Neurology in Clinical Practice, Eighth Edition, offers a straightforward style, evidence-based information, and robust interactive content supplemented by treatment algorithms and images to keep you up to date with all that's current in this fast-changing field. This two-volume set is ideal for daily reference, featuring a unique organization by presenting symptom/sign and by specific disease entities—allowing you to access content in ways that mirror how you practice. More than 150 expert contributors, led by Drs. Joseph Jankovic, John C. Mazziotta, Scott L. Pomeroy, and Nancy J. Newman, provide up-to-date guidance that equips you to effectively diagnose and manage the full range of neurological disorders. - Covers all aspects of today's neurology in an easy-to-read, clinically relevant manner. - Allows for easy searches through an intuitive organization by both symptom and grouping of diseases. - Features new and expanded content on movement disorders, genetic and immunologic disorders, tropical neurology, neuro-ophthalmology and neuro-otology, palliative care, pediatric...

Patología

Autor: Rafael Andrade P. , Rodrigo Restrepo M. , Alejandro Vélez H.

Número de Páginas: 648

Es un libro realizado con gran esfuerzo por parte de sus editores Esta nueva edición, la tercera, cuenta con 48 capítulos revisados por diferentes autores reconocidos en nuestro medio, los cuales han consignado los nuevos conceptos que en este momento prevalecen en nuestra ciencia médica, la cual se encuentra en cambio constante. Especialmente se han tenido en cuenta los conceptos de la biología y genética molecular, la ciencia del futuro, tan importante para estudiantes y profesionales del área de la salud. Además se incorporaron nuevas fotos, gráficos y cuadros en color que hacen mucho más amena la lectura de este texto.

Pathology Formulas

Autor: N.b. Singh

Número de Páginas: 143

"Pathology Formulas" is a concise and indispensable guide that distills complex concepts in pathology into a collection of essential formulas. Tailored for students, researchers, and professionals in the field of pathology, this book provides a quick reference for key equations and principles. Covering a range of pathological processes, the formulas aid in understanding disease mechanisms, diagnostic criteria, and treatment strategies. With clarity and precision, this handbook facilitates a deeper comprehension of pathology, making it an invaluable resource for those navigating the intricacies of disease pathology.

Precision Medicine in Neurodegenerative Disorders

Número de Páginas: 290

Precision Medicine in Neurodegenerative Disorders, Part One, Volume 192 in the Handbook of Clinical Neurology deals with the "Why" in the approach to slow the progression of accelerated brain aging. This volume is intended to provide a scholarly background on the framework, basic science and conceptual pitfalls related to disease-modifying efforts in Parkinson's, Alzheimer's and other neurodegenerative disorders. Among topics covered are different models of precision medicine, the lumping-versus-splitting tension in biomarker development and therapeutics, and the rationale for replacing the convergence of the prevailing autopsy-based nosology of neurodegenerative diseases with the divergence of a systems biology approach to human diseases. Specific chapters are dedicated to the promise of genetic subtypes and the lessons in disease modification offered by the fields of oncology and cystic fibrosis that can be adapted to the field of neurodegeneration. Matching a biology-correcting therapy with those biologically suitable to benefit from such therapy represents the vision and mission of precision medicine, the highest level of personalized medicine. - Summarizes theory and research ...

Advanced Imaging Methods in Neuroscience

Autor: João O. Malva , Jorge Valero , Miguel Castelo-branco , Alard Roebroeck

Número de Páginas: 498

Greenfield's Neuropathology, 2-Volume Set, Eighth Edition

Autor: Seth Love , David Louis , David W Ellison

Número de Páginas: 2285

Greenfield's Neuropathology, the worlds leading neuropathology reference, provides an authoritative, comprehensive account of the pathological findings in neurological disease, their biological basis and their clinical manifestations. This account is underpinned throughout by a clear description of the molecular and cellular processes and reactions that are relevant to the development, and normal and abnormal functioning of, the nervous system. While this scientific content is of paramount importance, however, care has been taken to ensure that the information is presented in a way that is accessible to readers working within a range of disciplines in the clinical neurosciences, and that also places the neuropathological findings within the context of a broader diagnostic process. The new eighth edition incorporates much new information, new illustrations and many new authors, while retaining the depth, breadth and quality of content so praised in previous editions. Each chapter opens with an introductory section designed to offer an integrated approach to diagnosis, taking account of clinical manifestations, neuroradiological and laboratory findings as well as the...

Essentials of Anatomic Pathology

Autor: Liang Cheng , David G. Bostwick

Número de Páginas: 2103

This much praised and widely used reference manual on has been extensively revised and expanded to cover the entire field of anatomic pathology. The Fourth Edition features the incorporation of full-color images in the text with updates of new diagnostic and prognostic information. New classifications and numerous new entities and histologic variants for each organ site will be fully incorporate in each individual chapter (Part II Organ Systems). Useful immunostaining biomarkers and emerging molecular targets and relevant molecular findings that have emerged from recent genomic studies are incorporated in each chapter. Written by internationally recognized authorities, the comprehensive, evidence-based practice information is presented in an outline format that is clear and easy to follow. Up-to-date and richly detailed, Essentials of Anatomic Pathology, Fourth Edition offers both the pathologist-in-training and the practicing pathologist a concise summary of all the critical information needed to recognize, understand and interpret anatomic pathology.

Biochemistry and Cell Biology of Ageing: Part II Clinical Science

Autor: J. Robin Harris , Viktor I. Korolchuk

Número de Páginas: 502

This volume of the subcellular Biochemistry series will attempt to bridge the gap between the subcellular events that are related to aging as they were described in the first volume of this set of two books and the reality of aging as this is seen in clinical practice. All chapters will start from the biochemistry or cell biology, where the data is available and work up towards the understanding that we have of aging in the various areas that are related to the subject. Key focus points for this volume are nutrition, external factors and genetics on aging. There will also be chapters that will focus on various organs or tissues in which aging has been well studied, like the eyes, the muscles, the immune system and the bones. The aim of the book project and the book project that is published in concert with this volume is to bring the subcellular and clinical areas into closer contact.

Essential Guide to Neurodegenerative Disorders

Autor: Wael Mohamed

Número de Páginas: 704

Handbook of Neurodegenerative Disorders: Mechanism, Diagnostic and Therapeutic Advances provides a comprehensive review on the current biomedical studies aimed at identifying the underlying causes of neurodegeneration. This book reviews the most recent developments in molecular and cellular processes altered during neurodegeneration. Divided into four parts, the first covers the mechanism of cell death in neurodegeneration. The second section reviews the recent progress in gene and gene products in neurodegeneration, including Huntington's disease, Parkinson's disease, Friedreich' s ataxia, and spinal muscular atrophy. The final sections cover the current and future diagnostic techniques of neurodegenerative disorders along with therapeutic approaches. - Reviews big data and neurodegeneration disorders, including gene mapping - Examines the structural basis of protein assembly into amyloid filaments in neurodegenerative disease - Covers the progress and challenges of pharmacotherapy of neurodegenerative disorders

Oxford Textbook of Old Age Psychiatry

Autor: Tom Dening , Alan Thomas

Número de Páginas: 860

The Oxford Textbook of Old Age Psychiatry, Second Edition, previously called Psychiatry in the Elderly, is an updated and revised version of this popular and highly respected textbook. The book has established itself as the standard textbook in its field due to its unique combination of comprehensive coverage, clear writing, and authoritative and up-to-date information. This new edition maintains these strengths, with chapters covering the basic sciences underpinning old age psychiatry, clinical practice, psychiatric services for older people, specific disorders, and medico-legal and ethical issues. This new updated edition involves 96 contributors from around the world bringing a truly global perspective to the textbook, and highlighting both the common burdens and the differences in management from country to country. New chapters have been included to reflect the development of old age care, covering palliative care, ethics of caring, and living and dying with dementia. Chapters have been revised and updated throughout with expanded chapters including those on brain stimulation therapies, memory clinics and services, and capacity, which has been extended to include all mental...

Greenfield's Neuropathology 10e Set

Autor: Colin Smith , Arie Perry , Gabor Kovacs , Thomas Jacques

Número de Páginas: 2210

Greenfield's is the world’s leading neuropathology reference. It provides a comprehensive account of the pathological findings in neurological disease, their biological basis, and their clinical manifestations. The two volume work provides a remarkable text which is clear, comprehensive and precise with exceptional illustrations. The tenth edition features fully updated sections covering CNS tumours, neurodegeneration, skeletal muscle, epilepsy, paediatric and forensic neuropathology.Expert coverage from an international team of Editors and contributors ensures authoritative and up to date content. The two volume set includes a downloadable and easily used e-version. This is a tried and tested reference for scientists, clinicians, researchers, and students who wish to learn more about neurological disease.

The Molecular and Cellular Basis of Neurodegenerative Diseases

Autor: Michael S. Wolfe

Número de Páginas: 561

The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer's, Parkinson's, frontotemporal dementia, ALS, Huntington's, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field. - Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical and cellular features - Focuses on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegeneration - Details features, advantages and...

Oxford Textbook of Cognitive Neurology and Dementia

Autor: Masud Husain , Jonathan M. Schott

Número de Páginas: 513

Now in paperback, this text covers the dramatic developments that have occurred in basic neuroscience and clinical research in cognitive neurology and dementia. The text is based on the clinical approach to the patient, and provides essential knowledge that is fundamental to clinical practice.

Essential Forensic Neuropathology

Autor: Juan C. Troncoso , Ana Rubio , David R. Fowler

Número de Páginas: 328

This book is written for pathologists and trainees in forensic pathology and neuropathology who will have to conduct forensic neuropathology autopsies. It will provide them with the basic knowledge to conduct a thorough postmortem examination of the nervous system, describe and document the relevant pathological changes, and interpret these findings in a way that will be helpful in determining the cause and manner of death. Great importance will be placed on the objective and rigorous documentation of the pathological findings, because many of these autopsy reports will be re-examined in the context of legal inquiries and proceedings. A companion Website will offer the fully searchable text, an image bank, and additional e-figures.

Neurodegeneration

Autor: Anthony Schapira , Zbigniew K. Wszolek , Ted M. Dawson , Nicholas Wood

Número de Páginas: 348

This book unites the diverse range of complex neurodegenerative diseases into a textbook designed for clinical practice, edited by globally leading authorities on the subject. Presents a clinically oriented guide to the diseases caused by neurodegeneration Templated chapters combine clinical and research information on neurodegenerative diseases beginning with the common elements before treating each disease individually Diseases are grouped by anatomical regions of degeneration and include common disorders such as Parkinson’s Disease, Alzheimer’s Disease, Amyotrophic Lateral Sclerosis/Motor Neuron Disease, and Multiple Sclerosis as well as less common diseases Edited by globally leading authorities on the subject, and written by expert contributing authors

Greenfield's Neuropathology Eighth Edition 2-Volume Set

Autor: Seth Love , David Louis , David W Ellison

Número de Páginas: 2224

Greenfield's Neuropathology, the worlds leading neuropathology reference, provides an authoritative, comprehensive account of the pathological findings in neurological disease, their biological basis and their clinical manifestations. This account is underpinned throughout by a clear description of the molecular and cellular processes and reactions that are relevant to the development, and normal and abnormal functioning of, the nervous system. While this scientific content is of paramount importance, however, care has been taken to ensure that the information is presented in a way that is accessible to readers working within a range of disciplines in the clinical neurosciences, and that also places the neuropathological findings within the context of a broader diagnostic process. The new eighth edition incorporates much new information, new illustrations and many new authors, while retaining the depth, breadth and quality of content so praised in previous editions. Each chapter opens with an introductory section designed to offer an integrated approach to diagnosis, taking account of clinical manifestations, neuroradiological and laboratory findings as well as the...

Greenfield's Neuropathology - Two Volume Set

Autor: Seth Love , Arie Perry , James Ironside , Herbert Budka

Número de Páginas: 1988

Greenfield's Neuropathology, the world’s leading neuropathology reference, provides a comprehensive account of the pathological findings in neurological disease, their biological basis, and their clinical manifestations. The book’s detailed advice on pathological assessment and interpretation is based on clear descriptions of molecular and cellular processes and reactions that are relevant to the development of the nervous system, as well as its normal and abnormal functioning. The information is presented in an accessible way to readers working within a range of disciplines in the clinical neurosciences, and neuropathological findings are placed within the context of a broader diagnostic process. New for the Ninth Edition: Features online and downloadable digital formats with rapid search functions, annotation and bookmarking facilities, image collections, and live reference links Contains many color illustrations and high-quality clinical photographs to help with interpretation and understanding Includes more than 1000 new photographs and drawings Incorporates new design elements, such as alternate colour coding of chapters for easier navigation Known for its thorough yet...

Applied Clinical Neuropsychology

Autor: Jan Leslie Holtz, Phd

Número de Páginas: 538

"Luring readers in...with meticulously woven clinical vignettes, Holtz masterfully presents the mechanics and the art of neuropsychology....students will appreciate the historical roots of neuropsychology, [and] will understand the multiplex systems of current neuropsychological approaches..." -Nancy S. Koven, PhD Bates College "...there has not been an available text focusing on the application of the basic principles in clinical neuropsychological practice....Finally, a text is available to remedy this problem." -Dennis Andersen, MS, LMHC Eastern Washington University "A valuable introduction to the field of clinical neuropsychology and its terminology, this text fills a void. The reader gains an appreciation for the multifaceted role of the clinical neuropsychologist, not only as an assessor of cognitive functioning but also as a treatment professional." Lauren Littlefield, PhD, Washington College This breakthrough introductory text-unlike all other clinical neuropsychology textbooks on the market-introduces advanced undergraduate students and clinicians in training to the field by showing undergraduate students how clinical neuropsychologists actually practice their craft. The ...

The Cambridge Handbook of Cognitive Aging

Autor: Ayanna K. Thomas , Angela Gutchess

Número de Páginas: 1048

Decades of research have demonstrated that normal aging is accompanied by cognitive change. Much of this change has been conceptualized as a decline in function. However, age-related changes are not universal, and decrements in older adult performance may be moderated by experience, genetics, and environmental factors. Cognitive aging research to date has also largely emphasized biological changes in the brain, with less evaluation of the range of external contributors to behavioral manifestations of age-related decrements in performance. This handbook provides a comprehensive overview of cutting-edge cognitive aging research through the lens of a life course perspective that takes into account both behavioral and neural changes. Focusing on the fundamental principles that characterize a life course approach - genetics, early life experiences, motivation, emotion, social contexts, and lifestyle interventions - this handbook is an essential resource for researchers in cognition, aging, and gerontology.

Pediatric Neuropathology

Autor: Serge Duckett

Número de Páginas: 994