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Pathways to Exploration

Pathways to Exploration

Autor: National Research Council , Division Of Behavioral And Social Sciences And Education , Committee On National Statistics , Division On Engineering And Physical Sciences , Space Studies Board , Aeronautics And Space Engineering Board , Committee On Human Spaceflight

Número de Páginas: 405

The United States has publicly funded its human spaceflight program on a continuous basis for more than a half-century, through three wars and a half-dozen recessions, from the early Mercury and Gemini suborbital and Earth orbital missions, to the lunar landings, and thence to the first reusable winged crewed spaceplane that the United States operated for three decades. Today the United States is the major partner in a massive orbital facility - the International Space Station - that is becoming the focal point for the first tentative steps in commercial cargo and crewed orbital space flights. And yet, the long-term future of human spaceflight beyond this project is unclear. Pronouncements by multiple presidents of bold new ventures by Americans to the Moon, to Mars, and to an asteroid in its native orbit, have not been matched by the same commitment that accompanied President Kennedy\'s now fabled 1961 speech-namely, the substantial increase in NASA funding needed to make it happen. Are we still committed to advancing human spaceflight? What should a long-term goal be, and what does the United States need to do to achieve it? Pathways to Exploration explores the case for...

Multiple Pathways to the Student Brain

Multiple Pathways to the Student Brain

Autor: Janet Zadina

Número de Páginas: 295

From an award-winning neuroscience researcher with twenty years of teaching experience, Multiple Pathways to the Student Brain uses educator-friendly language to explain how the brain learns. Steering clear of “neuro-myths,” Dr. Janet Zadina discusses multiple brain pathways for learning and provides practical advice for creating a brain-compatible classroom. While there are an abundance of books and workshops that aim to integrate education and brain science, educators are seldom given concrete, actionable advice that makes a difference in the classroom. Multiple Pathways to the Student Brain bridges that divide by providing examples of strategies for day-to-day instruction aligned with the latest brain science . The book explains not only the sensory/motor pathways that are familiar to most educators (visual, auditory, and kinesthetic), it also explores the lesser known pathways--reward/survival, language, social, emotional, frontal lobe, and memory/attention--and how they can be tapped to energize and enhance instruction. Educators are forever searching for new and improved ways to convey information and inspire curiosity, and research suggests that exploiting different...

GRASPED Pathways to Excellence

GRASPED Pathways to Excellence

Autor: Steven Brough

Número de Páginas: 62

"GRASPED Pathways to Excellence" is envisioned as a comprehensive guide aimed at individuals seeking transformation in both personal and professional spheres. It likely presents 20 innovative strategies designed to navigate through the complexities of achieving excellence, covering a broad spectrum from enhancing leadership skills, adopting new technologies for growth, to fostering personal well-being and creativity. This guide's USP may lie in its dual focus on personal and professional development, offering a holistic approach rarely found in traditional business or self-help books. It emphasizes the interconnectedness of personal well-being and professional success, providing readers with a unique toolkit designed for the modern landscape of work and life. An introduction to "GRASPED Pathways to Excellence" might set the stage for a transformative journey, highlighting the book's commitment to fostering growth, innovation, and balance. It could invite readers to explore new dimensions of success, promising not just strategies but a new perspective on excellence.

Cancer Stem Cells and Signaling Pathways

Cancer Stem Cells and Signaling Pathways

Autor: Surajit Pathak , Antara Banerjee

Número de Páginas: 703

Cancer Stem Cells and Signaling Pathways explores the mechanism of cancer stem cell signaling pathways in cancer advancement, serving as an ideal reference guide for investigators with valuable answers to problems associated with anti-cancer treatments and an understanding of the crosstalk among the signaling pathways in CSC regulation. Despite recent advances in tumor therapy and a greater understanding of their biology, tumors continue to be a prevalent and fatal worldwide. According to a novel paradigm in tumor biology, a small percentage of the cells within a tumor known as cancer stem cells (CSCs) are predicted as a crucial population for tumor progression. - Presents cancer stem characteristics and their signaling pathways - Highlights the use of animal models for cancer research, the use of genetically modified stem cells to deliver antitumor agents, and the significance of stem cell signaling in drug discovery - Covers basic and translational research appropriate for scientists and clinicians exploring alternative treatments for various cancers

Cell and molecular signaling, and transport pathways involved in growth factor control of synaptic development and function

Cell and molecular signaling, and transport pathways involved in growth factor control of synaptic development and function

Autor: Akira Yoshii , Martha Constantine-paton , Nancy Y. Ip

Número de Páginas: 114

Brain derived neurotophic factor (BDNF) and its receptor tropomyosin receptor kinase B (TrkB) signaling has been extensively studied for its roles in the central nervous system (CNS) ranging from cell survival, axonal and dendritic growth and synapse formation. Intracellular signaling pathways triggered by BDNF activate gene transcription, translation, post-translational functions, trafficking of key synaptic proteins, and synaptic release mechanism. BDNF-TrkB signaling mediates long-lasting activity-modulated synaptic changes on excitatory and inhibitory neurons and plays significant roles in circuit development and modulation. Furthermore, this pathway is critical for learning, memory, sensory processing and other cognitive functions, and is implicated in neurological and psychiatric diseases. In addition to BDNF, more recent studies have identified new “growth” factors that play important roles in the development, maturation and maintenance and modulation of synaptic function. However, details of the cytoplamic signaling systems downstream of these synaptogenic factors are often less understood than conventional neurotophin signaling. This e-Book has collected original...

Pathway Analysis for Drug Discovery

Pathway Analysis for Drug Discovery

Autor: Anton Yuryev

Número de Páginas: 332

This book introduces drug researchers to the novel computational approaches of pathway analysis and explains the existing applications that can save time and money in the drug discovery process. It covers traditional computational methods and software for pathway analysis microarray, proteomics, and metabolomics. It explains pathway reconstruction of diseases and toxic states, pathway analysis in various phases, dynamic modeling of drug responses, and more. This is a core resource for drug discovery and pharmaceutical industry researchers, chemists, and biologists and for professionals in related fields.

GRASPED Pathways to Entrepreneurial Mastery

GRASPED Pathways to Entrepreneurial Mastery

Autor: Steven Brough

Número de Páginas: 63

"GRASPED Pathways to Entrepreneurial Mastery" unfolds as an insightful guide to mastering the dual realms of business and personal growth. With 20 essential strategies, it covers innovation, leadership, digital transformation, and personal well-being. The book is structured to offer practical advice, real-world examples, and actionable steps for entrepreneurs aiming for success in both their professional and personal lives. What sets this guide apart is its holistic approach, seamlessly blending business acumen with personal development. It's unique in offering a dual path to mastery, emphasizing the synergy between personal well-being and entrepreneurial success, thus equipping readers for the challenges of a rapidly evolving business landscape while also fostering personal integrity and growth. Embark on a transformative journey with "GRASPED Pathways to Entrepreneurial Mastery." This book is a beacon for ambitious individuals, guiding them through the complexities of entrepreneurship while also nurturing personal growth. It's designed not just as a business guide but as a comprehensive roadmap to achieving a harmonious balance between professional achievements and personal...

Signalling Pathways in Embryonic Development

Signalling Pathways in Embryonic Development

Autor: Juan J. Sanz-ezquerro , Andrea E. Münsterberg , Sigmar Stricker

Número de Páginas: 179

The formation of a complex multicellular organism from a single cell is one of the most amazing processes of biology. Embryonic development is characterised by the careful regulation of cellular behaviours such that cells proliferate, migrate, differentiate and form tissues at the correct place and time. These processes are genetically controlled and depend both on the history of cells, their lineage, and on the activities of signalling pathways, which coordinate the cell interactions leading to organogenesis. The aim of the Frontiers research topic “Signalling pathways in embryonic development” has been to provide a forum for experts in cell and developmental biology to share recent advances in the field of signalling during embryonic development. Sixteen articles in a variety of formats are united in this Topic, offering a valuable collection for researchers looking for an update in the knowledge of signalling pathways operating during embryogenesis. The works, focused mainly on vertebrates, explore different aspects of this theme from cell communication to organ formation and have implications for areas as distant as evolution or pathology. Understanding developmental...

Climate Change 2022 - Mitigation of Climate Change

Climate Change 2022 - Mitigation of Climate Change

Autor: Intergovernmental Panel On Climate Change (ipcc)

Número de Páginas: 2042

This Working Group III contribution to the IPCC Sixth Assessment Report provides a comprehensive and transparent assessment of the literature on climate change mitigation. The report assesses progress in climate change mitigation options for reducing emissions and enhancing sinks. With greenhouse gas emissions at the highest levels in human history, this report provides options to achieve net zero, as pledged by many countries. The report highlights for the first time the social and demand-side aspects of climate mitigation, and assesses the literature on human behaviour, lifestyle, and culture, and its implications for mitigation action. It brings a wide range of disciplines, notably from the social sciences, within the scope of the assessment. IPCC reports are a trusted source for decision makers, policymakers, and stakeholders at all levels (international, regional, national, local) and in all branches (government, businesses, NGOs). Available as Open Access on Cambridge Core.

Emerging Stronger

Emerging Stronger

Autor: Jeffrey Chin , Michele Lee Kozimor

Número de Páginas: 199

Responding to the sudden and far-reaching implications of the COVID-19 pandemic in college classrooms and on campus, Emerging Stronger assembles an original compilation of chapters that revisit, reframe, and refine the practice of teaching in a fundamentally altered landscape. Cultivated from a wide array of different fields, from sociology and political science to literature and secondary education, expert contributors to this volume extend their scholarship on teaching and learning and offer thoughtful pieces about curricular innovation, teaching tools and techniques, and evidence-based approaches that will interest dedicated faculty in any discipline. The chapters fall into three categories—Modalities of Teaching and Learning, Pedagogical Strategies, and Student Engagement—each of which carry an all-important focus on what readers should know about best practices now and for the foreseeable future. Whether experienced faculty, scholars just starting out in their teaching careers, or aspiring graduate students, readers of this volume will come away with great techniques and strategies, but also community, hope, and opportunity to strengthen their teaching and provide better...

Modern Graph Theory Algorithms with Python

Modern Graph Theory Algorithms with Python

Autor: Colleen M. Farrelly , Franck Kalala Mutombo

Número de Páginas: 290

Solve challenging and computationally intensive analytics problems by leveraging network science and graph algorithms Key Features Learn how to wrangle different types of datasets and analytics problems into networks Leverage graph theoretic algorithms to analyze data efficiently Apply the skills you gain to solve a variety of problems through case studies in Python Purchase of the print or Kindle book includes a free PDF eBook Book DescriptionWe are living in the age of big data, and scalable solutions are a necessity. Network science leverages the power of graph theory and flexible data structures to analyze big data at scale. This book guides you through the basics of network science, showing you how to wrangle different types of data (such as spatial and time series data) into network structures. You’ll be introduced to core tools from network science to analyze real-world case studies in Python. As you progress, you’ll find out how to predict fake news spread, track pricing patterns in local markets, forecast stock market crashes, and stop an epidemic spread. Later, you’ll learn about advanced techniques in network science, such as creating and querying graph databases, ...

Immunometabolism and Metabolic Reprogramming of immune cells in human physiology and disease

Immunometabolism and Metabolic Reprogramming of immune cells in human physiology and disease

Autor: Soumya R. Mohapatra , Christiane A. Opitz

Número de Páginas: 181
Bioinformatics

Bioinformatics

Autor: Hamid D. Ismail

Número de Páginas: 469

Bioinformatics: A Practical Guide to NCBI Databases and Sequence Alignments provides the basics of bioinformatics and in-depth coverage of NCBI databases, sequence alignment, and NCBI Sequence Local Alignment Search Tool (BLAST). As bioinformatics has become essential for life sciences, the book has been written specifically to address the need of a large audience including undergraduates, graduates, researchers, healthcare professionals, and bioinformatics professors who need to use the NCBI databases, retrieve data from them, and use BLAST to find evolutionarily related sequences, sequence annotation, construction of phylogenetic tree, and the conservative domain of a protein, to name just a few. Technical details of alignment algorithms are explained with a minimum use of mathematical formulas and with graphical illustrations. Key Features Provides readers with the most-used bioinformatics knowledge of bioinformatics databases and alignments including both theory and application via illustrations and worked examples. Discusses the use of Windows Command Prompt, Linux shell, R, and Python for both Entrez databases and BLAST. The companion website...

Emerging Bioinformatic Tools in Toxicogenomics

Emerging Bioinformatic Tools in Toxicogenomics

Autor: Danyel Jennen , Paul Jennings

Número de Páginas: 148

Toxicogenomics was established as a merger of toxicology with genomics approaches and methodologies more than 15 years ago, and considered of major value for studying toxic mechanisms-of-action in greater depth and for classification of toxic agents for predicting adverse human health risks. While the original focus was on technological validation of in particular microarray-based whole genome expression analysis (transcriptomics), mainly through cross-comparing different platforms for data generation (MAQC-I), it was soon appreciated that actually the wide variety of data analysis approaches represents the major source of inter-study variation. This led to early attempts towards harmonizing data analysis protocols focusing on microarray-based models for predicting toxicological and clinical end-points and on different methods for GWAS data (MAQC-II). Simultaneously, further technological developments, geared by increasing insights into the complexity of cellular regulation, enabled analyzing molecular perturbations across multiple genomics scales (epigenomics and microRNAs, metabolomics). While these were initially still based on microarray technology, this is currently being...

Comparative Vertebrate Neuroanatomy

Comparative Vertebrate Neuroanatomy

Autor: Ann B. Butler , William Hodos

Número de Páginas: 756

Comparative Vertebrate Neuroanatomy Evolution and Adaptation Second Edition Ann B. Butler and William Hodos The Second Edition of this landmark text presents a broad survey of comparative vertebrate neuroanatomy at the introductory level, representing a unique contribution to the field of evolutionary neurobiology. It has been extensively revised and updated, with substantially improved figures and diagrams that are used generously throughout the text. Through analysis of the variation in brain structure and function between major groups of vertebrates, readers can gain insight into the evolutionary history of the nervous system. The text is divided into three sections: * Introduction to evolution and variation, including a survey of cell structure, embryological development, and anatomical organization of the central nervous system; phylogeny and diversity of brain structures; and an overview of various theories of brain evolution * Systematic, comprehensive survey of comparative neuroanatomy across all major groups of vertebrates * Overview of vertebrate brain evolution, which integrates the complete text, highlights diversity and common themes, broadens perspective by a...

What’s Transgressive about Trans* Studies in Education Now?

What’s Transgressive about Trans* Studies in Education Now?

Autor: Z Nicolazzo

Número de Páginas: 243

During the past few years, a nascent body of theoretical, conceptual, and empirical research in the field of higher education has emerged regarding transgender students, faculty, and staff. An exciting trend among some of this work is the use of critical and poststructural paradigms, data collection methods, and analytical tools through which to make sense of and articulate findings. In this special issue, authors push the boundaries of what is understood to be the queer theoretical canon. Additionally, they explore the experience of transgender people in higher education environments from methodological, theoretical, and empirical perspectives, foregrounding the recent scholarship, from some of the leading scholars in the field of higher education doing transgender-related research. This book was originally published as a special issue of International Journal of Qualitative Studies in Education.

Graph Transformations

Graph Transformations

Autor: Hartmut Ehrig

Número de Páginas: 462

This book constitutes the refereed proceedings of the Second International Conference on Graph Transformation, ICGT 2004, held in Rome, Italy, in September/October 2004. The 26 revised full papers presented together with three invited contributions and summaries of 2 tutorials and 5 workshops were carefully reviewed and selected from 58 submissions. The papers are organized in topical sections on integration technology, chemistry and biology, graph transformation concepts, DPO theory for high-level structures, analysis and testing, graph theory and algorithms, application conditions and logic, transformation of special structures, and object-orientation.

Mayo Clinic Medical Neurosciences

Mayo Clinic Medical Neurosciences

Autor: Eduardo E. Benarroch , Jeremy K. Cutsforth-gregory , Kelly D. Flemming

Número de Páginas: 777

Fully updated and revised according to student feedback, the sixth edition of Mayo Clinic Medical Neurosciences: Organized by Neurologic System and Level provides a systematic approach to anatomy, physiology, and pathology of the nervous system inspired by the neurologist's approach to solving clinical problems. This volume has 4 sections: 1) an overview of the neurosciences necessary for understanding anatomical localization and pathophysiologic characterization of neurologic disorders; 2) an approach to localizing lesions in the 7 longitudinal systems of the nervous system; 3) an approach to localizing lesions in the 4 horizontal levels of the nervous system; and 4) a collection of clinical problems. This book provides the neuroscience framework to support the neurologist in a clinical setting and is also a great resource for neurology and psychiatry board certifications. This is the perfect guide for all medical students and neurology, psychiatry, and physical medicine residents at early stages of training. New to This Edition - A chapter devoted to multiple-choice questions for self-assessment - Discussion of emerging concepts in molecular, cellular, and system neurosciences - ...

Interventional Cardiac Electrophysiology

Interventional Cardiac Electrophysiology

Autor: Ralph J. Damiano, Jr., Md, Facc, Facs , N.a. Mark Estes Iii, Md, Facc, Fhrs, Faha, Fesc , Francis E. Marchlinski, Md, Facc, Fhrs, Faha

Número de Páginas: 1046

Interventional Cardiac Electrophysiology is the first and only comprehensive, state-of-the-art textbook written for practitioners in multiple specialties involved in the care of the arrhythmia patient. Encompassing the entire field of interventional therapy for cardiac rhythm management, from basic science to evidence-based medicine to future directions, topics include: Technology and Therapeutic Techniques – EP techniques; imaging and radiologic technology; device and ablation technology; drug therapy.Interventional Electrophysiologic Procedures – Diagnostic and physiologic EP techniques; mapping in percutaneous catheter and surgical EP procedures; catheter and surgical ablation; device implantation and management.Clinical Indications and Evidence-based Outcomes Standards – For medical and surgical EP interventions for arrhythmias.New Directions in Interventional Electrophysiology – Hybrid therapy for atrial and ventricular arrhythmias and staged therapy. This book will be essential reading for clinicians and researchers that form the health care team for arrhythmia patients: cardiologists, adult and pediatric clinical electrophysiologists, interventional...

Handbook of Molecular Microbial Ecology I

Handbook of Molecular Microbial Ecology I

Autor: Frans J. De Bruijn

Número de Páginas: 1155

The premiere two-volume reference on revelations from studying complex microbial communities in many distinct habitats Metagenomics is an emerging field that has changed the way microbiologists study microorganisms. It involves the genomic analysis of microorganisms by extraction and cloning of DNA from a group of microorganisms, or the direct use of the purified DNA or RNA for sequencing, which allows scientists to bypass the usual protocol of isolating and culturing individual microbial species. This method is now used in laboratories across the globe to study microorganism diversity and for isolating novel medical and industrial compounds. Handbook of Molecular Microbial Ecology is the first comprehensive two-volume reference to cover unculturable microorganisms in a large variety of habitats, which could not previously have been analyzed without metagenomic methodology. It features review articles as well as a large number of case studies, based largely on original publications and written by international experts. This first volume, Metagenomics and Complementary Approaches, covers such topics as: Background information on DNA reassociation and use of 16 rRNA and other DNA...

Network Bioscience, 2nd Edition

Network Bioscience, 2nd Edition

Autor: Marco Pellegrini , Marco Antoniotti , Bud Mishra

Número de Páginas: 270

Network science has accelerated a deep and successful trend in research that influences a range of disciplines like mathematics, graph theory, physics, statistics, data science and computer science (just to name a few) and adapts the relevant techniques and insights to address relevant but disparate social, biological, technological questions. We are now in an era of 'big biological data' supported by cost-effective high-throughput genomic, transcriptomic, proteomic, metabolomic data collection techniques that allow one to take snapshots of the cells' molecular profiles in a systematic fashion. Moreover recently, also phenotypic data, data on diseases, symptoms, patients, etc. are being collected at nation-wide level thus giving us another source of highly related (causal) 'big data'. This wealth of data is usually modeled as networks (aka binary relations, graphs or webs) of interactions, (including protein-protein, metabolic, signaling and transcription-regulatory interactions). The network model is a key view point leading to the uncovering of mesoscale phenomena, thus providing an essential bridge between the observable phenotypes and 'omics' underlying mechanisms. Moreover,...

Key Topics in Healthcare Management

Key Topics in Healthcare Management

Autor: Robert Jones

Número de Páginas: 262

Focusing on matters relevant to the development, provision and maintenance of best quality services for patients, clients and service users, this title presents management, leadership and professional development advice to allied health professions.

Movement Control

Movement Control

Autor: Paul Cordo , Stevan Harnad

Número de Páginas: 296

Movement is arguably the most fundamental and important function of the nervous system. Purposive movement requires the coordination of actions within many areas of the cerebral cortex, cerebellum, basal ganglia, spinal cord, and peripheral nerves and sensory receptors, which together must control a highly complex biomechanical apparatus made up of the skeleton and muscles. Beginning at the level of biomechanics and spinal reflexes and proceeding upward to brain structures in the cerebellum, brainstem and cerebral cortex, the chapters in this book highlight the important issues in movement control. Commentaries provide a balanced treatment of the articles that have been written by experts in a variety of areas concerned with movement, including behaviour, physiology, robotics, and mathematics.

Green Grades

Green Grades

Autor: Graham Bullock

Número de Páginas: 410

A comprehensive assessment and analysis of the validity, trustworthiness, and effectiveness, of such environmental ratings as ENERGY STAR, LEED, and USDA Organic. Consumers are confronted with a confusing array of environmental ratings on products that range from refrigerators to shampoos. Is the information that these ratings represent trustworthy, accurate, or even relevant to environmental concerns? “Information optimists” believe that these “green grades” can play an important role in saving the planet. “Information pessimists” consider them a distraction from pursuing legislative and regulatory actions. In this book, Graham Bullock offers a comprehensive assessment and analysis of the effectiveness and validity of such environmental ratings as ENERGY STAR, USDA Organic, the Forest Stewardship Council, LEED, and the Toxic 100 Air Polluters Index. Bullock stakes out a position as an “information realist,” acknowledging both the contributions and the limitations of these initiatives. Drawing on interviews, case studies, and an original dataset of 245 environmental ratings and certifications, he examines what he calls the information value chain of green grades:...

Bioinformatics and Biomedical Engineering

Bioinformatics and Biomedical Engineering

Autor: Ignacio Rojas , Francisco Ortuño , Fernando Rojas , Luis Javier Herrera , Olga Valenzuela

Número de Páginas: 380

This volume constitutes the proceedings of the 11th International Work-Conference on IWBBIO 2023, held in Gran Canaria, Spain, during July 15-17, 2022. The 54 full papers were carefully reviewed and selected from 148 submissions. They were organized in the following topical sections: Biomarker Identification, Biomedical Engineering, Biomedical Signal Analysis, E-Health.

Direct Nose-to-Brain Drug Delivery

Direct Nose-to-Brain Drug Delivery

Autor: Chandrakantsing Pardeshi , Eliana B. Souto

Número de Páginas: 556

Direct Nose-to-Brain Drug Delivery provides the reader with precise knowledge about the strategies and approaches for enhanced nose-to-brain drug delivery. It highlights the development of novel nanocarrier-based drug delivery systems for targeted drug delivery to the brain microenvironments with a focus on the technological advances in the development of the novel drug delivery devices for intranasal administration, including special emphasis on brain targeting through nose. This book explores the various quantification parameters to assess the brain targeting efficiency following intranasal administration and includes an overview on the toxicity aspects of the various materials used to develop the direct nose-to-brain drug delivery vehicles and of the regulatory aspects including patents and current clinical status of the potential neurotherapeutics for the effective management of neuro-ailments. Technological advances in new drug delivery systems with diverse applications in pharmaceutical, biomedical, biomaterials, and biotechnological fields are also explained. This book is a crucial source that will assist the veteran scientists, industrial technologists, and clinical...

It's about Time

It's about Time

Autor: Phyllis Moen

Número de Páginas: 451

How do two-career couples manage in a one-career world?It's about Time examines this mismatch between outdated scripts and the experiences of dual-earner couples. It broadens our understanding of occupational and family career strategies couples use in light of the widening gap between their real lives and the outdated work-hour and career-path roles, rules, and regulations they confront. It's about Time draws on the data from the Cornell Couples and Careers Study to demonstrate that:*Regardless of income, time is a scarce commodity in dual-earner households. With two jobs, two commutes, often long work hours, high job demands, business travel, several cars, children, ailing relatives, and/or pets - time is always an issue.*Time is built into jobs and career paths in ways that make continuous full-time (40 or typically more hours a week) paid work a fact of life in American society. *The multiple strands of life—career, family and personal—unfold over time. Spouses move through their life courses in tandem, with early choices - to have children or not, to work long hours or not, to switch jobs or not, to relocate for his or her career or not—all having long-term consequences ...

Scientific Frontiers in Developmental Toxicology and Risk Assessment

Scientific Frontiers in Developmental Toxicology and Risk Assessment

Autor: National Research Council , Commission On Life Sciences , Board On Environmental Studies And Toxicology , Committee On Developmental Toxicology

Número de Páginas: 347

Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific...

Biochemical Aspects of Metabolic Disorders

Biochemical Aspects of Metabolic Disorders

Autor: Muhammad Sajid Hamid Akash , Kanwal Rehman

Número de Páginas: 864

Biochemical Aspects of Metabolic Disorders offers a comprehensive exploration of the intricate biochemical mechanisms and/or pathways underlying a wide array of metabolic disorders. From the genetic basis of inherited metabolic conditions to the environmental factors impacting metabolic dysregulation, each chapter investigates the molecular insights essential for understanding and managing these complex diseases. Covering topics such as carbohydrate and lipid metabolism disorders, amino acid catabolism, hepatic and renal metabolism, mitochondrial dysfunction, pediatric obesity, and diagnostic approaches, this book will serve as a requisite resource for researchers, clinicians, and students alike looking for unravel the biochemical intricacies of metabolic disorders. - Provides comprehensive coverage of various aspects of metabolic disorders, including carbohydrate and lipid metabolism disorders and amino acid metabolism disorders - Offers detailed molecular insight into the biochemical mechanisms and/or pathways involved in metabolic disorders, helping readers understand the underlying mechanisms driving disease pathogenesis - Includes diagnostic algorithms and therapeutic...

Mapping COVID-19 in Space and Time

Mapping COVID-19 in Space and Time

Autor: Shih-lung Shaw , Daniel Sui

Número de Páginas: 356

This book describes the spatial and temporal perspectives on COVID-19 and its impacts and deepens our understanding of human dynamics during and after the global pandemic. It critically examines the role smart city technologies play in shaping our lives in the years to come. The book covers a wide-range of issues related to conceptual, theoretical and data issues, analysis and modeling, and applications and policy implications such as socio-ecological perspectives, geospatial data ethics, mobility and migration during COVID-19, population health resilience and much more. With accelerated pace of technological advances and growing divide on political and policy options, a better understanding of disruptive global events such as COVID-19 with spatial and temporal perspectives is an imperative and will make the ultimate difference in public health and economic decision making. Through in-depth analyses of concepts, data, methods, and policies, this book stimulates future studies on global pandemics and their impacts on society at different levels.

Therapeutic Mechanism of Osteosarcoma

Therapeutic Mechanism of Osteosarcoma

Autor: Yang Wang , Tong-chuan He , Yang-fan Lv

Número de Páginas: 144

Osteosarcoma (OS) is the most common primary bone tumor, with a bimodal age distribution. The highest incidence is in children and adolescents, and the second highest is among older adults (>60 years). Surgery and neoadjuvant chemotherapy are the main clinical treatments for OS, yet the 5-year survival rate is just 20% for individuals with metastases or recurrent OS. Most standard treatments were established in the 1980s, which can achieve long-term survival in approximately 60% of patients with localized OS. However, in the face of inoperable surgery, we are still limited in what we can do for OS patients who are insensitive or intolerant to chemotherapy drugs. Resistance to chemotherapeutic drugs is also a problem that hinders breakthroughs in OS treatment. Although survival rates have not improved during the past four decades, the heterogeneity and potential molecular aberrations of OS have been revealed as the biology of OS has come to be better understood. With the recent advancements in molecular profiling technology for OS, new technologies and concepts are undergoing sublimation.

Clinical Arrhythmology and Electrophysiology

Clinical Arrhythmology and Electrophysiology

Autor: Ziad F. Issa , John Michael Miller , Douglas P. Zipes

Número de Páginas: 519

With its unique, singular focus on the clinical aspect of cardiac arrhythmias, Clinical Arrhythmology and Electrophysiology: A Companion to Braunwald's Heart Disease makes it easy to apply today's most up-to-date guidelines for diagnosis and treatment. An expert author team provides clear, clinically focused guidance on all types of cardiac arrhythmias, including practical techniques for managing complex patients. Find the information you need quickly with a consistent organization in all chapters, written to a template that shows every arrhythmia type in a similar manner. Access the fully searchable contents online at www.expertconsult.com, in addition to downloadable images and dynamic video clips. Fully understand the rationale for treatment of specific arrhythmias with practical techniques that are grounded in the most recent basic science. Stay up to date with new chapters on molecular mechanisms of cardiac electrical activity, cardiac ion channels, ventricular tachycardia in nonischemic dilated cardiomyopathy, epicardial ventricular tachycardia, ventricular arrhythmias in hypertrophic cardiomyopathy, ventricular arrhythmias in inherited channelopathies, ventricular...

Final Environmental Impact Statement on the Disposal of Decommissioned, Defueled Naval Submarine Reactor Plants

Final Environmental Impact Statement on the Disposal of Decommissioned, Defueled Naval Submarine Reactor Plants

Autor: United States. Navy Department

Número de Páginas: 522
Biochemistry, International Adaptation

Biochemistry, International Adaptation

Autor: Donald Voet , Judith G. Voet

Número de Páginas: 1490

The "Gold Standard" in Biochemistry text books.Biochemistry 4e, is a modern classic that has been thoroughly revised. Don and Judy Voet explain biochemical concepts while offering a unified presentation of life and its variation through evolution. It incorporates both classical and current research to illustrate the historical source of much of our biochemical knowledge

Forest Hydrology

Forest Hydrology

Autor: Devendra Amatya , Thomas Williams , Leon Bren , Carmen De Jong

Número de Páginas: 309

Forests cover approximately 26% of the world's land surface area and represent a distinct biotic community. They interact with water and soil in a variety of ways, providing canopy surfaces which trap precipitation and allow evaporation back into the atmosphere, thus regulating how much water reaches the forest floor as through fall, as well as pull water from the soil for transpiration. The discipline "forest hydrology" has been developed throughout the 20th century. During that time human intervention in natural landscapes has increased, and land use and management practices have intensified. The book will be useful for graduate students, professionals, land managers, practitioners, and researchers with a good understanding of the basic principles of hydrology and hydrologic processes.

Practical Applications in Sports Nutrition

Practical Applications in Sports Nutrition

Autor: Heather Hedrick Fink , Alan E. Mikesky

Número de Páginas: 529

Practical Applications in Sports Nutrition, Seventh Edition provides students with the latest sports nutrition information and dietary practices enabling them to assist athletes and fitness enthusiasts in achieving their personal performance goals. Drawing from the latest data and statistics from nutrition research and guidelines, the authors demonstrate effective ways to communicate sports nutrition messages to athletes and outline how to motivate individuals to make permanent behavior change. Early chapters introduce sports nutrition and give a thorough explanation of macronutrients, micronutrients, and water, and their relation to athletic performance. Later chapters focus on the practical and applied aspects of sports nutrition including behavior change through consultations and weight management.

The Adaptation and Response of Aquatic Animals in the Context of Global Climate Change

The Adaptation and Response of Aquatic Animals in the Context of Global Climate Change

Autor: Hongsheng Yang , John I. Spicer , Juan D. Gaitan-espitia

Número de Páginas: 255

Anthropogenic climate change has driven widespread changes in marine environments, including ocean warming, ocean acidification, and the formation of hypoxic zones. Such environmental changes would pose direct challenges to the survival and adaptation of aquatic organisms, greatly affecting the biodiversity of marine life and marine ecosystems. Changes in the marine environment are likely to have strong effects at the physiological, behavioral, and molecular levels, with implications at the individual, population, and species levels, resulting in the degradation of genetic resources through massive mortality. For example, the ingestion, digestion, respiration, and growth of aquatic animals were greatly depressed under extreme environments. In the long run, maintaining a sustainable ocean would require a better understanding of the adaptation of marine animals in response to the effects of multiple environmental stressors. The Research Topic is aimed to discuss the potential impacts of individual and compounded extreme environments on aquatic animals, as well as the regulatory mechanisms and adaptation strategies of marine species to cope with these impacts.

Clinical Radiation Oncology

Clinical Radiation Oncology

Autor: Leonard L. Gunderson

Número de Páginas: 570

First Prize winner, Oncology Book Category, British Medical Association 2012 Medical Book Competition Deepen your knowledge with a comprehensive, clinical approach to the scientific foundations of radiation oncology and general oncology as well as state-of-the-art techniques and modalities. Implement a multidisciplinary, "team care" approach to providing intricate treatment plans for patients, often in conjunction with medical oncologists, and surgeons. Broaden your understanding of the basic biology of the disease processes. Examine the therapeutic management of specific disease sites based on single-modality and combined-modality approaches. Quickly and easily find critical information thanks to an easily accessible, full-color design with over 800 color figures that clearly depict treatment techniques. Get broad multimodality perspectives and unique insights from a diverse team of respected editors and contributors -many of whom are new to this edition - affiliated with institutions across North America and internationally Access the fully searchable text anywhere, anytime at www.expertconsult.com, along with references, additional images and tables, video clips and more! Stay...

Chemotherapy and Surgery in Colon Cancer: for Better Treatment Outcomes

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Autor: Xinxiang Li , Mirko Omejc , Chang-in Choi , Qi Liu

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Regulation of Adult Stem Cells Fate and Function in Natural and Artificial Microenvironments

Regulation of Adult Stem Cells Fate and Function in Natural and Artificial Microenvironments

Autor: Pavel Makarevich , Andrei S. Chagin , Yu-chen Hu

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